We herby report a case of primary mediastinal pure. Syncytiotrophoblasts, large eosinophilic smudgy multinucleated cells with known, large hyperchromatic nuclei, are intermixed. Bibek bhandari astha shrestha benju pandit iind batch 2. We use your linkedin profile and activity data to personalize ads and to show you more relevant ads. Choriocarcinoma is a rare, extremely malignant type of tumour arising from the trophoblast. Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Gross pathology of avian diseases top results of your surfing gross pathology of avian diseases start download portable document format pdf and e books electronic books free online rating news 20162017 is books that can provide inspiration, insight, knowledge to the reader. Choriocarcinoma article about choriocarcinoma by the. Sep 29, 2011 choriocarcinoma is a complicated condition that can create problems in pregnancy and even lead to lifethreatening disorders. Ebook gross pathology of avian diseases as pdf download. Surgical pathology dissection an illustrated guide second edition william h. Such cases are called gestational trophoblastic neoplasm until pathology is confirmed. It is a malignancy of placental origin in which the trophoblastic cells of the uterus undergo malignant alteration that causes improper progress of the. If the testis is biopsied, it is usually for fertility.
Pure choriocarcinoma of the testis is rare, accounting for only 0. High hcg levels greater than 100,000 miuml prognostic factors. The diagnosis of diseases of women 1905 14760098631. Choriocarcinomas resemble the cells that surround an embryo in the uterus. Sep 07, 2019 testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors nsgcts, which along with testicular seminoma constitute the two major histologic groups of testicular cancers.
While references are made to the more encyclopedic pathology of the human placenta, this manual is designed as a userfriendly, easytoread bench manual that can be used in the grossing room as well as at the microscope. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students. We report a surgically treated case of choriocarcinoma in a 37yearold woman who came to our attention because of a isolated lung. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated.
Free pathology books download ebooks online textbooks. Primary choriocarcinoma of the lung is extremely uncommon. It is more common in women, but may also affect men. When it is associated with gestation, it is often considered part of the spectrum of gestational trophoblastic disease. Malignant trophoblastic tumor comprising a trimorphic proliferation of syncytiotrophoblast, cytotrophoblast and intermediate trophoblast with. Commonly, symptoms or test results can indicate choriocarcinoma. Microscopic view of choriocarcinoma taken from the uterus illustrated in figure 9. Choriocarcinoma occurs after pregnancy in 1 in 30,000 pregnancies in the united states 33. A baby may or may not develop in this type of pregnancy. Grossly, choriocarcinoma is a soft, friable tumor with extensive. The prognosis of this tumor is extremely poor, despite surgical and chemotherapeutic treatment. As with choriocarcinomas in general, it is a highly vascular neoplasm. Choriocarcinoma is one of the tumors that are very responsive to chemotherapy, except for the case of choriocarcinoma in the testicles.
Choriocarcinoma transactions of a conference of the international union against cancer. Primary nongestational pure choriocarcinoma arising in the ovary. An unusual case of primary choriocarcinoma of the lung. On gross examination the resected small intestine measured 14 cm in length. Choriocarcinoma is a rare type of tumor that happens in women during pregnancy. Choriocarcinoma online pathology video lecturio online. Case report successful treatment of choriocarcinoma with. A study of choriocarcinoma its incidence in india and its aetiopathogenesis. Choriocarcinomas resemble the cells that surround an. Choriocarcinoma is pathology confirmed malignancy of the trophoblast cell of the placenta. Upon gross inspection, the mass predominantly consisted of. Epidemiology, clinical features, gross features, and histopathology have.
General pathology covers the basic mechanisms of diseases whereas systemic pathology covers diseases as they occur in each organ system. Choriocarcinoma symptoms, treatment, prognosis cancerworld. Description of textbook of pathology, this is the 7th edition of textbook of pathology by harsh mohan, i look back with satisfaction how this book has grown phenomenally since its modest beginning in 1992. Manual of pathology of the human placenta springerlink.
Testicular tumors are the most common malignancies among american men between the ages of 20 and 39 years. Choriocarcinoma is a rare cancer that occurs as an. Part of the uicc monograph series book series uicc, volume 3 log in to check access. This book is intended to be a textbook of general pathology for health science students.
The testis, plural testes, are important for survival of the species. It has a fast spread to the lungs even early in the disease. Median in one series of testicular choriocarcinoma 200,000 iu. Choriocarcinoma is defined by the presence of syncytiotrophoblast cells intimately admixed with cytotrophoblast cells. Nov 15, 2004 we describe an unusual case of metastatic choriocarcinoma of the pancreas arising from a regressing testicular mixed germ cell tumor that clinically mimicked a primary pancreatic tumor. Apr 17, 2003 choriocarcinoma is an aggressive neoplasm arising in the body of the uterus. It is characterized by early hematogenous spread to the lungs. Choriocarcinoma is a malignant germ cell tumor gct that shows trophoblastic differentiation and resembles extraembryonic chorion. Choriocarcinoma is a germ cell tumor containing syncytiotrophoblastic cells and secreting human betahcg. Sir, primary choriocarcinoma of the mediastinum occurs in both sexes, but is extremely rare. Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus.
Currently, he is director of gynecologic pathology service, clinical. It is an aggressive form of cancer originating from the trophoblast cells in the placenta. The prognosis of primary mediastinal choriocarcinoma is still very poor despite the introduction of combination chemotheraphy including cisplatin. In situ or intraplacental choriocarcinoma has been well documented to occur in fullterm placentas. Choriocarcinoma is a complicated condition that can create problems in pregnancy and even lead to lifethreatening disorders. Choriocarcinoma is a malignancy of placental origin.
In the case of gestational choriocarcinoma, approximately 5% of cases of complete hydatidiform mole are followed by choriocarcinoma. Common metastatic sites include lung, brain, liver, kidney and bowel. Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. Elevation may be seen in other nontrophoblastic tumours. Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors nsgcts, which along with testicular seminoma constitute the two major histologic groups of testicular cancers. We report a surgically treated case of choriocarcinoma in a 37yearold woman who came to our. Fetus is rarely involved, even in cases of widespread metastatic disease. An unusual case of primary choriocarcinoma of the lung bmc. Choriocarcinoma starts as a gestational trophoblastic disease and progresses to a malignancy. Distinction of these subtypes has prognostic and therapeutic implications. Part of the uicc monograph series book series uicc, volume 3 log in to. There is no difference in pathological appearances between gestational type and nongestational pure choriocarcinoma. Gestational trophoblastic disease diagnostic and molecular.
This is the organ that develops during pregnancy to feed the fetus. Untreated choriocarcinoma characteristically presents with early hematogenous metastases. Read and know all about this disease including its causes, symptoms, diagnosis and treatment. Gestational primary ovarian choriocarcinoma is extremely rare, with an estimated incidence of 1 in 3.
Manual of pathology of the human placenta, second edition is a concise, practical manual of placental pathology. Imaging features of a primary tumor are dependent on location. Sheets of anaplastic trophoblastic cells are noted without the maintenance of the pattern of the villi. Gross appearance of choriocarcinoma, consisting of a hemorrhagic mass involving the endomyometrium. Choriocarcinoma is a type of gestational trophoblastic disease. Choriocarcinoma symptoms, prognosis, treatment, diagnosis. Below are 200 highyield general pathology points which serve as a quick revision for memorizing important general pathology concepts from exam point of view. Department of pathology department of pathology the johns hopkins university the johns hopkins university school of medicine school of medicine baltimore, maryland baltimore, maryland timothy h. Malignant transformation in a hydatidiform mole is rare event.
The reasons that normal chorionic cells undergo cancerous change, with exaggeration of their natural and potent tendency to invade the uterine muscle and break down blood vessels, are unknown. Choriocarcinoma definition a choriocarcinoma is type of cancer germ cell containing trophoblast cells. The abnormal cells start in the tissue that would normally become the placenta. In 1977 8, it was observed that using a combination of gross, histologic and. Choriocarcinoma symptoms,causes,diagnosis and treatment. Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. The cancer may also occur after a normal pregnancy. Choriocarcinoma is a malignant, trophoblastic cancer, usually of the placenta. Choriocarcinoma is defined by the presence of syncytiotrophoblast cells.
The text throughout is current and thoroughly referenced. An overview of testicular germ cell tumors archives of. General pathology lecture notes for health science students. Gestational choriocarcinoma follows normal pregnancy 25%, spontaneous abortion 25%, and hydatidiform mole 50%, but only about 35% of all molar pregnancies eventuate in choriocarcinoma. The extensive necrosis, vascular penetration, and hemorrhage are evident from this specimen. Choriocarcinoma is a fastgrowing cancer that occurs in a womans uterus womb.
The cutup of orchiectomy specimens is dealt with in orchiectomy grossing. Choriocarcinoma symptoms, treatment, prognosis choriocarcinoma is a category of gestational trophoblastic disease which is quickgrowing form of cancer that occurs in a womans uterus womb. Choriocarcinoma is an aggressive, highly vascular tumor. Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells. Pathology characteristic feature is the identification of intimately related syncytiotrophoblasts and cytotrophoblasts without formation of definite placental type villi. Choriocarcinoma is pathologyconfirmed malignancy of the trophoblast cell of the placenta. Dr hui is a boardcertified surgical pathologist with clinical specialty areas including gynecologic pathology and molecular diagnostics. Patients with no metastases have a high recovery rate. Medics told the shocked couple that tammie, 29, had choriocarcinoma, a type of persistent trophoblastic, very rare pregnancyrelated tumour. It is also classified as a germ cell tumor and may arise in the testis or ovary.
Since choriocarcinomas include syncytiotrophoblasts betahcg producing cells, they cause elevated blood levels of betahuman chorionic gonadotropin. However, when metastases are already present in the brain and liver, the condition is usually fatal. Download fulltext pdf download fulltext pdf case study of choriocarcinoma following a term pregnancy article pdf available in acta medica mediterranea 32. Pure nongestational choriocarcinoma is a primary germ cell neoplasm. On histology, there is an absence of chorionic villi c. We describe an unusual case of metastatic choriocarcinoma of the pancreas arising from a regressing testicular mixed germ cell tumor that clinically mimicked a primary pancreatic tumor. Help support this site, yourself, or your loved one visit the bookstore to purchase print or digital copies of the my molar pregnancy book collections, which contain dozens of womens experiences with molar pregnancy or choriocarcinoma from diagnosis to recovery.
Dna patterns from tumor and maternal tissue, as well as villous tissue from any available prior or concurrent gestation, were compared, to determine gestational versus nongestational nature containing vs. This is a growth that forms inside the womb at the beginning of a pregnancy. But it most often occurs with a complete hydatidiform mole. Choriocarcinoma transactions of a conference of the. It belongs to the malignant end of the spectrum in gestational trophoblastic disease gtd. In this volume dr hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities. Media in category choriocarcinoma this category contains only the following file. Unusual presentation of choriocarcinoma world journal of. May present initially with metastases liver, lung, mediastinum, retroperitoneum with normal testis or small tumor but with increased serum hcg. He joined the pathology faculty at yale university, new haven, connecticut, in 2001 and became full professor in 20. Choriocarcinoma most often follows a molar pregnancy but may. Metastasis may be clinically solitary and may occur in unusual locations and often present with massive hemorrhage. After treatment with chemo, you can still get pregnant again.
Description choriocarcinomas are cancers that develop from germ cells, cells that ordinarily turn into sperm or eggs. Choriocarcinoma is an uncommon malignant neoplasm, which can be either gestational or nongestational in origin. On gross examination, a circumscribed hemorrhagic mass is observed. Early hematogenous spread to lungs, liver and brain. Gestational trophoblastic tumors archives of pathology. Highyield general pathology notes for usmle step 1fcps part 1. Pdf case study of choriocarcinoma following a term pregnancy.